KMID : 0368820110500060428
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Journal of the Korean Neuropsychiatr Association 2011 Volume.50 No. 6 p.428 ~ p.433
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The Effects of Adjuvant Therapy of Atypical Antipsychotics on the Change of Clinical Symptoms in Patients with Major Depressive Disorder in a University Hospital: 1 Year Follow-Up Study
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Park Hyung-Woo
Na Churl Min Kyung-Jun Han Doug-Hyun
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Abstract
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Objectives: This study is to assess the effects of adjuvant therapy of atypical antipsychotics on the change clinical symptoms in patients with major depressive disorder.
Methods: We conducted a chart review of patients, who visited a university hospital. Ninety seven patients were divided into two groups : patients with adjuvant use of antipsychotics with antidepressants (AD+AAP ; n=32) and patients with only antidepressants (AD ; n=65). We compared and analyzed three clinical domains including depressive symptoms, anxiety symptoms and sleep qualities between two groups. Depressive symptoms, Anxiety symptoms, and sleep pattern were evaluated by Beck¡¯s Depression Inventory (BDI), Beck¡¯s Anxiety Inventory (BAI), and Pittsburgh Sleep Quality Index (PSQI) at baseline (first day of admission) and 1 year later.
Results: During 1 year, the BDI scores of AD+AAP group has been greatly decreased, compared to AD group (F=5.87, p=0.02). In the comparison of patients with severe symptoms of major depressive disorder (BDI score >21), there was significant difference in the change of BDI score between AD+AAP and AD (F=4.14, p=0.04). After 1 year, there were no significant differences in BAI score change (F=0.51, p=0.47), PSQI score change (F=0.89, p=0.35) between two group. However, the duration of adjunctive therapy and the type of atypical antipsychotics would not impact the results.
Conclusion: Current study suggested that adjuvant therapy of atypical antipsychotics would be effective on depressive symptoms in patients with severe major depressive disorder, compared to the treatment with antidepressants alone.
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KEYWORD
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Depressive disorder, Atypical antipsychotics, Antidepressants, Adjunctive therapy
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